We have been developing a closed-type production system for transgenic plants which produce recombinant pharmaceuticals. This facility consists of two areas, transgenic plant cultivation area and pharmaceutical production area. In this facility, transgenic plants (such as strawberry, rice, potato, tobacco, and soybean) which produce pharmaceuticals can be cultivated in a completely artificial environment. In cultivation area, temperature, humidity, CO2 concentration, etc. could be controlled automatically. To prevent genetic contamination, pollens are removed by HEPA filter from air, and culture solution and waste materials are discarded after sterilization. At pharmaceutical production area, extraction and processing of pharmaceuticals from cultivated plants.