Bioproduction Research Institute (BPRI) was established in AIST Hokkaido in 2010 as one of research institutes in National Institute of Advanced Industrial Science and Technology (AIST).

2001	Research Institute of Biological Resources (predecessor institute) was established in connection with the re-organization of new AIST. The first director was Dr. Tatsuo Katsura. The institute consisted of 7 research groups.
2002	The institute established a collaborative chair in Graduate School of Agriculture, Hokkaido University. The institute was reorganized and named Research Institute for Biological Resources and Functions.
2003	Dr. Hiroshi Kuriyama was appointed to the second director. The institute established a collaborative chair in Graduate School of Science, Hokkaido University.
2004	Reseach Institute of Genome-based Biofactory (RIGB) was established by the division of Research Institute for Biological Resources and Functions. BPRI consisted of 8 research groups at the initial phase. Dr. Fumio Mizutani was appointed to the third director.
2006	Dr. Yoichi Kamagata was appointed to the fourth director. One group (Gene regulation research group) in the AIST Tsukuba center merged with the institute.
2007	Three groups in the institute were merged to form two new groups.
2008	Biology and Ecophysiology Research Team was inaugurated.
2010	Teams of Synthetic Glycocojugate Research and Bio Photo Imaging Research were inaugurated. Symbiotic Evolution and Biological Functions Research Group was inaugurated
2012	Bioproduction Research Institute was established by the combining of research groups in Reseach Institute of Genome-based Biofactory, Institute for Biological Resources and Functions, and Research Institute for Cell Engineering.
2014	Dr. Tomohiro Tamura is appointed to the fifth director.
2015	Applied Molecular Microbioloty Research Group, new Synthetic Bioengneering Research Group, and Molecular Systems Bioengineering Research Team were inaugurated.
2016	Molecular and Biological Technology Research Group and Bio-material Engineering Research Group are merged.
2018	Functional Food Materials Research Team was inaugurated.
2019	Dr. Kaoru Suzuki is appointed to the sixth director.