As mentioned above, we are promoting research projects funded by public institutions and private companies employing our knowledge regarding the 16S rRNA gene-based microbial community analysis and functional gene-based metagenomic analysis for a wide range of natural and artificial ecosystems: intestinal tracts of insects and fish, agricultural soil, paddy fields, desert, polar environments, terrestrial subsurface, plant roots, mixed culture systems, and municipal sewage/industrial wastewater treatment processes. We aim to improve the industrial ecosystem for upcoming sustainable circular economy by comprehensive understanding of the biosphere ecosystem through microbiology informatics.